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As I Suspected: You Do Not Need High Weight To Bulk/tone
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This is just one example, but at about ~1:20 in, you can see the result of numerous studies on numerous patient groups. The results are striking in their similarity: both low-repetition, high intensity (weight) and high-repetition, lower intensity (weight) sets produced equivalent results, when performed to fatigue or failure. Of course, you have to use enough weight to produce SOME kind of challenge, but men, you do not, not, not need to use the biggest stack of weight possible to "get big" and muscular. The big stacks of weight are the result of lots of bulking up, not the cause (confusing these two is like believing that not having dandruff causes people to use anti-dandruff shampoo, instead of the other way around; it's an easy mistake to make if you just connect the dots -- hey, people without dandruff use anti-dandruff shampoo, therefore... -- and scientists/skeptics call this confusing correlation with causation).
Similarly, ladies, higher weights will not cause you to bulk up. Most of you ladies (and many of us men) simply lack the testosterone needed to produce significant muscle bulk, so make sure you're using enough weight to be challenging, or all that toning work will be for nothing.
Finally, it doesn't really matter how much weight you use (as long as it's enough to be eventually challenging, of course). There's no difference between "toning" exercise and "bulking" exercise -- challenging your muscles through any route will produce the same physiological neuromuscular changes, over the long run. Whether you "tone" (get long, lean muscles) or "bulk" (get large, bulky muscles) is almost entirely due to your physiology and hormones, and NOT due to the type of sets you do.
I'd suspected this for a time (some of the biggest, bulkiest bodybuilders at my gym seem to consistently be doing large numbers of lower-weight sets), so it's good to see it confirmed scientifically. I'm sure that some folks will simply dismiss it out of hand, as it goes against the received gospel of bodybuilding. But it's good to know what science says; I'm happy to learn that I don't have to use huge weights that increase my pain and risk of injury, in order to produce the same advantage. The real key -- like with anything -- is consistency, pushing my limits, and arming myself with knowledge of how my body works.
Edit: I forgot to mention this, but it's important. This has ONLY to do with muscle fitness and strength. It has NOTHING to do with training for a particular athletic activity. For instance, to be a good basketball player, you need a certain amount of muscular strength, and for that either high weights/low reps, or low weights/high reps will work. But you also need to train the shots, the defense, the strategy, the cardio endurance, and so on. For these things, the equation is completely different. My post is only about bulking/strengthening/toning muscles, where the amount of weight used is irrelevant.