Question for gastric bypasser’s who take Duloxetine/Cymbalta: do you take the capsule whole or open/sprinkle the contents into food?

I have been opening/sprinkling since surgery but read somewhere that we shouldn’t. My concern is if we don’t, then capsule could pass through us whole, largely intact with less absorption? My Dr. did comment that as long as I take it I will need to take Pepcid to prevent ulcers. I tried to go off it last week but musculoskeletal and nerve pain from last year’s back surgery returned with intensity so started back on it 30 minutes ago. Any input will be greatly appreciated!?

Edited May 3, 20206 yr by Lily66

I had my surgery on 1/29/19 and was told just to take the capsule. I didn't have any issues or side effects from it. I hope whatever you decide to do, that you feel and heal well.

Edited May 4, 20206 yr by Lamermaid

Thanks, Lamermaid! I took it whole yesterday and will continue to. It absolutely amazes me how much it helps with long term pain and slight mood lift. They started me on it a year ago prior to having microdiscectomy at L5 S1. At the time, he said it would greatly reduce nerve pain associated with herniated disc and surgery, and lessen the anxiety surrounding it. Started on 30mg, built to 60mg. My liver enzymes became elevated (they also had me on mega doses of prescription NSAIDS, steroids, etc.) so we discontinued all meds except Duloxetine, brought that down to 30mg and enzymes returned to normal. I’ve remained on 30mg since.

In researching this weekend, I found they came out with Duloxetine in a sprinkle form last year, under the name Drizalma Sprinkle. Retail price here in FL is over $200/monthly, and even with my insurance it has a $100 copay. Once the patent runs out price should come down. Thanks again for sharing your experience and continued best wishes to you!