I am 3 1/2 weeks out from surgery and have had no problems with Heart burn until today. I haven't eaten anything different in the past week. I have taken my PPI regularly only missing one day, that was yesterday. Could it be because I missed it yesterday?

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Taking a PPI has been shown clinically to create dependence on PPI drugs to control acid, instead of allowing your stomach to adjust to the new size and adjust acid levels. When people with no GERD symptoms were given a PPI for just a few weeks, fully half of them developed GERD when they stopped taking the PPI.

If you miss taking it, that's most likely responsible for a sudden flare up. When you stop taking it in a few months, you can expect more of the same.