If you're quick to heal and rebound (like I am), you will probably be fine physically, but you will need to plan your meals. You will most likely be on liquids (maybe pureed at that time depending on your plan) which can be challenging in certain environments. If you will be staying in a home - no problem, if you are staying in a hotel you'll need to think through how to manage your nutrition.
Also, most people find that while they are physically fine, there are repercussions that they are dealing with (less stamina as your body adjusts to a longer term calorie deficit), soreness, mental and emotional fatigue, irritability, etc.)
Also you may want to consider how "food centric" your vacation will be. Some things (and some people) are heavily oriented around food/eating. It really supported me in the first 6 weeks not to be around what I considered food oriented activities. While on liquids I just MISSED EATING. I missed the taste of food, I missed chewing, I just missed it.
That did pass after the first two months, but I also had very little of those kinds of activities in my environment and that really worked for me and let me keep my mind focused on other things.