Jump to content
×
Are you looking for the BariatricPal Store? Go now!

Understanding the mechanics of fat cells



Recommended Posts

According to the internet:

Adipose tissue, or fat, is an anatomical term for loose connective tissue composed of adipocytes. Its main role is to store energy in the form of fat, although it also cushions and insulates the body.

Excess adipose tissue (fat cells) can lead to problematic changes in metabolism, blood sugar control and blood pressure. Recently scientist have been exploring the role of fat cells acts on the brain to signal satiety (hunger control).

More recently, researchers have been delving into the mechanisms that adipose tissue uses to affect other parts of the body. A recent report in the journal Nature investigates one possible source of such control. To describe the study we have to define a couple of terms:

microRNA (miRNA): small (19-22 nucleotides long) segments of RNA that do not code for Proteins. There are many different types of miRNAs in the circulation and in different tissues, and they have various functions in the body. In general, they act to prevent translation of mRNAs and thus decrease the production of the corresponding proteins.

Dicer: an enzyme found in adipose as well as other tissues that processes miRNAs — without it miRNAs aren't produced.

Led by Dr. C. Ronald Kahn of the Joslin Diabetes Center of Harvard University, researchers bred so-called 'knockout' mice that lacked the Dicer enzyme in adipose tissue specifically. These adipose-tissue-specific Dicer knockout (ADicerKO) mice did not produce the usual complement of miRNAs found in normal mice, showing that adipose tissue is responsible for making a large number of the circulating miRNAs. And this is important, because the presence of such miRNAs is associated with improvements in glucose tolerance and other beneficial metabolic changes.

Indeed, the ADicerKO mice exhibited a decrease in brown adipose tissue (the most metabolically active type), as well as an increase in insulin resistance. However, when both brown and white adipose tissue from normal mice was transplanted into the knockout mice, they began to produce the miRNAs, demonstrating the importance of the adipose tissue in circulating miRNA production.

In addition to their work with the mice, the investigators also compared miRNAs from patients with lipodystrophy [1] with those from control people. They found that the patients with lipodystrophy had lower levels of over 200 different miRNAs compared to the controls.

Thus, both the animal and human data suggest an important role for adipose tissue in the regulation of metabolism, and may indicate an important avenue for future research into the roles of Dicer and miRNAs in the obesity-linked derangement of blood pressure, blood glucose regulation and insulin resistance.

http://acsh.org/news/2017/03/02/when-fat-speaks-body-listens-10911

Share this post


Link to post
Share on other sites

Interesting! Thanks!



Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

  • Trending Products

  • Trending Topics

  • Recent Status Updates

    • amazingmimi

      I feel like I've finally gotten past the biggest hurdle. Surgery date is September 6th, the day after Labor Day, and yesterday I got my insurance approval letter. I've followed everything they've told me to do, and I've even lost 30 lbs on my own since hubby had to change his diet for diabetes. No worries now about having to do 4 weeks of the liver shrinking diet instead of 2. On my initial visit, if I had gained just 5lbs I would have had to do 4 weeks. It's getting closer. Just 2 more months to wait.
      · 1 reply
      1. NmMd

        Although the prep work took energy, I found the biggest hurdle was post-operative. The first 48 hrs were extremely uncomfortable. I did an overnight and trying to down the liquids, Tylenol, and especially the barium was rough. Thankfully though, I got away with only having to have 1 belly injection after surgery. Needless are not my thing.

    • Grace1234

      I am brand new to this my surgery is tentative for July 27 depending on insurance and I'll be have the Gastric Sleeve.
      · 0 replies
      1. This update has no replies.
    • Pepper1

      I am looking for people to connect with that are 4-5 years out. Many of the support sights I go to are all newbies. And while I enjoyed that when i first had my surgery and found it useful, I am looking to exchange ideas with folks that are out a few years. I am slowly gaining weight back and losing my excitement. I don't want that!
      · 1 reply
      1. SleeverSk

        Maybe post in the forums. It's a more active areaI have noticed no one replies to status updates

    • SuziDavis

      I have a surgery date! I am getting sleeved on 8/17/2022!
      · 0 replies
      1. This update has no replies.
    • Mudh8r

      How do you stay focused? I'm struggling a bit the past three days.  All I want is sweets and carbs.  I have no clue what changed but for some reason I'm craving hard.  I'm literally dreaming about food and when I wake up, I'm thinking about my next meal.  I'm not "hungry" but so munchy.  I'm trying to stay focused, busy, exercise and the likes but this looking struggle is getting to be so hard.  I meet with my nutritionist tomorrow and I'm so hopeful she has some advice.  My protein intake is great, liquids on point, even throwing in some raw veggies and berries to curb the sweet/carb craving.  Thoughts?
      · 1 reply
      1. SleeverSk

        I am like this at the moment too, maybe post in the forums and not as your status update you will get more replies

  • Recent Topics

  • Hot Products

  • Sign Up For
    Our Newsletter

    Follow us for the latest news
    and special product offers!
  • Together, we have lost...
      lbs

    PatchAid Vitamin Patches

    ×