Chanelle, my heart is going out to you.
On doing a cursory search of the academic medical journals on pregnancy after bariatric surgery (because as of yet, I have not found one which encompasses 'surgery whilst pregnant' and I concede the procedures documented do not encompass VSG), I found the following. Go straight to the abstracts/conclusions to get the gist of the research and findings. Sorry to everyone else for the information splat taking up your screens.
This is clearly not merely an issue of the fetus being exposed to radiation through an x-ray or the impact of the anesthesia on the fetus during the VSG procedure (which is not to be overlooked and if you'd like me to send you a complete article privately, I can - 'cause it's very long to post here and you'd need to read all of it to get the baseline). It is also about the severe nutritional, Vitamin and mineral deficiencies present in the first weeks after the operation which appear to have a significant impact on the progress of the fetuses growth and development in utero. A point that would need significant evaluation, monitoring and intensive hands-on care. If you would like to ask any questions on the below, please do not hesitate to contact me.
Much love x
Analgesia, Anaesthesia and Pregnancy A Practical Guide
3rd Edition
By Steve Yentis Chelsea and Westminster Hospital, London By Surbhi Malhotra St Mary’s Hospital, London
Publisher: Cambridge University Press
Print Publication Year:2012
Online Publication Date:December 2012
Online ISBN:9781139012966
Paperback ISBN:9781107601598
Book DOI: http://dx.doi.org/10.1017/CBO9781139012966
Subjects: Anesthesia, Intensive Care, Pain Management ,Obstetrics and Gynecology, Reproductive Medicine
Chapter 3
Anaesthesia before conception or
confirmation of pregnancy
Many women will require anaesthesia when they are pregnant and many will be unaware that
they are pregnant at the time of the anaesthetic, especially in the first 2–3 months of their
pregnancy. The thalidomide catastrophe initiated the licensing arrangements for new drugs and
their use in pregnancy; the current cautious stance of the pharmaceutical industry is reflected in
the British National Formulary’s statement that no drug is safe beyond all doubt in early
pregnancy. The anaesthetist should have a clear knowledge of the time scale of the developing
fetus in order to balance the risks and benefits of any drug given to the mother. A teratogen is a
substance that causes structural or functional abnormality in a fetus exposed to that substance.
Problems/special considerations
The possible effect of a drug can be considered against the stage of the developing fetus:
Pre-embryonic phase (0–14 days post-conception): The fertilised egg is transported down
the Fallopian tube and implantation occurs at around 7 days post-conception. The
conceptus is a ball of undifferentiated dividing cells during this time and the effect of
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drugs on it appears to be an all-or-none phenomenon. Cell division may be slowed with
no lasting effects or the conceptus will die, depending on the severity of the cell damage.
Embryonic phase (3–8 weeks post-conception): Differentiation of cells into the organs and
tissues occurs during this phase and drugs administered to the mother may cause
considerable harm. The type of abnormality that is produced depends on the exact stage
of organ and tissue development when the drug is given.
Fetal phase (9 weeks to birth): At this stage, most organs are fully formed, although
the cerebral cortex, cerebellum and urogenital tract are still developing. Drugs
administered during this time may affect the growth of the fetus or the functional
development within specific organs.
Management options
The anaesthetist should always consider the possibility of pregnancy in any woman of child-
bearing age who presents for surgery, whether elective or emergency, and should specifically
enquire in such cases. If there is doubt, a pregnancy test should be offered. If pregnancy is
suspected, the use of nitrous oxide is now generally considered acceptable, despite its effects
on methionine synthase and DNA metabolism, as there is little evidence that it is harmful
clinically. Similarly, although the volatile agents have been implicated in impairing embryonic
development, clinical evidence is lacking. Some drugs cross the placenta and exert their effect
on the fetus, e.g. warfarin, which may cause bleeding in the fetus.
Key points
The possibility of pregnancy should be considered in any woman of childbearing age.
No drug is safe beyond all doubt in pregnancy.
Further reading
Allaert SE, Carlier SP, Weyne LP, et al. First trimester anesthesia exposure and fetal outcome.
A review. Acta Anaesthesiol Belg 2007; 58: 119–23.
6 Section 1: Preconception and conception
Pregnancy shortly after bariatric surgery.
Transliterated Title: Svangerskap like etter fedmeoperasjon. Authors: Skogøy K; kristin.skogoy@nordlandssykehuset.no Laurini R Aasheim ET Source: Tidsskrift For Den Norske Lægeforening: Tidsskrift For Praktisk Medicin, Ny Række [Tidsskr Nor Laegeforen] 2009 Mar 12; Vol. 129 (6), pp. 534-6. Publication Type: Case Reports; English Abstract; Journal Article Language: Norwegian Journal Info: Publisher: Norske Laegeforening Country of Publication: Norway NLM ID: 0413423 Publication Model: Print Cited Medium: Internet ISSN: 0807-7096 (Electronic)Linking ISSN: 00292001 NLM ISO Abbreviation: Tidsskr. Nor. Laegeforen. Subsets: MEDLINE Imprint Name(s): Publication: Oslo : Norske Laegeforening Original Publication: Chistiania : Alb. Cammermeyer, 1880- MeSH Terms: Bariatric Surgery/*adverse effects Pregnancy Complications/*etiology Adult ; Bariatric Surgery/methods ; Duodenum/surgery ; Female ; Fetal Development ; HELLP Syndrome/etiology ; Humans ; Infant, Newborn ; Infant, Small for Gestational Age ; Obesity, Morbid/metabolism ; Obesity, Morbid/surgery ; Pregnancy ; Pregnancy Complications/metabolism ; Pregnancy Outcome ; Risk Factors; Time Factors ; Ultrasonography, Prenatal ; Weight Loss
Abstract: Bariatric surgery is increasingly used to treat morbidly obese patients. Fertility in women may be enhanced after these procedures, owing to substantial weight loss and possibly a decreased absorption of oral contraceptives. We report a pregnancy that occurred two months after biliopancreatic diversion with duodenal switch in a 32-year-old woman. She subsequently developed haemolysis, elevated liver enzymes and low platelets count (HELLP) syndrome and had a weight loss of 43 kg (from the bariatric procedure) until the infant was delivered preterm by caesarean section (due to low activity). The infant was small in relation to the gestational age, with a weight of less than 50 % of the expected (780 g at 29.6 weeks). Histological examination demonstrated a small placenta with insufficient spiral artery trophoblast infiltration, possibly caused either by severe preeclampsia or by maternal nutritional deficiencies. Severe metabolic aberrations may complicate pregnancies after malabsorptive bariatric surgery. Patient preparations before weight-loss operations should include information on fertility and birth control in the postoperative period. Protocols for monitoring of patients that become pregnant after bariatric surgery are needed.
Comments: Comment in: Tidsskr Nor Laegeforen. 2009 Mar 12;129(6):536-7. (PMID: 19291887) Entry Date(s): Date Created: 20090317 Date Completed: 20090319 Latest Revision: 20110330 Update Code: 20131125 DOI: 10.4045/tidsskr.09.34019 PMID: 19291886 Database: MEDLINE with Full Text
The risk of adverse pregnancy outcome after bariatric surgery:
a nationwide register-based matched cohort study
Mette Mandrup Kjær, MD; Jeannet Lauenborg, MD, PhD; Birger Michael Breum, MD; Lisbeth Nilas, DMSc
OBJECTIVE: The aim of this study was to describe the risk of adverse
obstetric and neonatal outcome after bariatric surgery.
STUDY DESIGN: Nationwide register-based matched cohort study of
singleton deliveries after bariatric surgery during 2004-2010. Data
were extracted from The Danish National Patient Registry and The Med-
ical Birth Register. Each woman with bariatric surgery (exposed) was in-
dividually matched with 4 women without bariatric surgery (unexposed)
on body mass index, age, parity, and date of delivery. Continuous vari-
ables were analyzed with the paired t test and binary outcomes were
analyzed by logistic regression.
RESULTS: We identied 339 women with a singleton delivery after bari-
atric surgery (84.4% gastric bypass). They were matched to 1277 un-
exposed women. Infants in the exposed group had shorter mean gesta-
tional age (274 vs 278 days; P .001), lower mean birthweight (3312
vs 3585 g; P .001), lower risk of being large for gestational age (ad-
justed odds ratio, 0.31; 95% condence interval, 0.15– 0.65), and
higher risk of being small for gestational age (SGA) (adjusted odds ratio,
2.29; 95% condence interval, 1.32–3.96) compared with infants in
the unexposed group. No statistically signicant difference was found
between the groups regarding the risk of gestational diabetes mellitus,
preeclampsia, labor induction, cesarean section, postpartum hemor-
rhage, Apgar score less than 7, admission to neonatal intensive care
unit or perinatal death.
CONCLUSION: Infants born after maternal bariatric surgery have lower
birthweight, lower gestational age, 3.3-times lower risk of large for ges-
tational age, and 2.3-times higher risk of SGA than infants born by a
matched group of women without bariatric surgery. The impact on SGA
was even higher in the subgroup with gastric bypass.
Key words: adverse pregnancy outcome, bariatric surgery, gastric
bypass, pregnancy
Pregnancy after bariatric surgery: a current view of maternal,
obstetrical and perinatal challenges
Ronis Magdaleno Jr • Belmiro Gonc¸ alves Pereira •
Elinton Adami Chaim • Egberto Ribeiro Turato
Received: 6 May 2011 / Accepted: 14 December 2011 / Published online: 29 December 2011
Ó Springer-Verlag 2011
Abstract With the increase in the number of bariatric
surgeries being performed in women of childbearing age,
physicians must have concerns regarding the safety of
pregnancy after bariatric surgery. The aim of this review is
to summarize the literature reporting on maternal, obstet-
rical and perinatal implications of pregnancy following BS.
Methods English, Spanish and Portuguese-language arti-
cles were identied in a PUBMED search from 2005 to
February 2011 using the keywords for pregnancy and
bariatric surgery or gastric bypass or gastric banding.
Results The studies show improved fertility and a
reduced risk of gestational diabetes, pregnancy-induced
hypertension and pre-eclampsia, macrosomia in pregnant
women after bariatric surgery. The incidence of intrauter-
ine growth restriction and small for gestational age are
increased. No conclusions can be drawn concerning the
risk for cesarean delivery and the best surgery- to-conception interval. Deciencies in Iron, Vitamin A,
vitamin B12, vitamin K, folate and Calcium can result in
maternal and fetal complications.
Conclusions Pregnancy outcome of women who deliv-
ered after BS, as compared to obese populations, is better
and safer and comparable to the general population. Close
supervision before, during and after pregnancy following
bariatric surgery and nutrient supplementation adapted to
the patient’s individual requirements can prevent nutrition-
related complications and improve maternal and fetal
health.
Keywords Bariatric surgery
Pregnancy Pregnancy
complications
Morbid obesity Weight loss
Vitamin A Deficiency in Pregnancy: Perspectives after Bariatric Surgery
Cristiane Barbosa Chagas1, 2, Cláudia Saunders3, 4, 5, Silvia Pereira1, 6, 2, Jacqueline Silva7, 2,Carlos Saboya8, 9, 6, 2 and Andréa Ramalho3, 10, 11
(1)Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
(2)Center for Research on Micronutrients, Josué de Castro Institute of Nutrition, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
(3)FIOCRUZ, Rio de Janeiro, Brazil
(4)Nutrition and Dietetics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
(5)Research Group in Maternal and Child Health (GPSMI), Josué de Castro Institute of Nutrition, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
(6)Clínica Cirúrgica Carlos Saboya, Rio de Janeiro, Brazil
(7)Human Nutrition, Center for Research on Micronutrients, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
(8)Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
(9)Brazilian Society for Bariatric and Metabolic Surgery, São Paulo, Brazil
(10)Social Applied Nutrition Department, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
(11)Instituto de Nutrição Josué de Castro, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373. Edifício dos Institutos Bloco J, 2° andar, sala 26, Ilha do Fundão, 21941-590 Rio de Janeiro, Brazil
Andréa Ramalho
Email: aramalho.rj@gmail.com
Published online: 12 December 2012
Abstract
This study aims to describe the clinical consequences of vitamin A deficiency (VAD) in pregnant women after bariatric surgery. Included are studies on VAD during pregnancy and after bariatric surgery conducted in humans from 1993 to 2011. There are few investigations on the relationship between pregnancy and bariatric surgery and on the damage to the binomial mother–child resulting from VAD in this relationship. The high percentage of VAD in the postoperative period is a cause for concern, especially considering the function of this vitamin in certain biological moments and in moments of intense nutritional demand. This vitamin serum evaluation is recommended during the prenatal period.
Keywords Pregnancy Vitamin A Vitamin A deficiency Obesity Bariatric surgery Retinol Beta carotene Night blindness