Yes, I have been on Byetta since October 2005 and initially lost 64 lbs on it over I year. Then I started to gain the weight back. According to Lily, it is not meant for weight loss though and I does help to regulate blood sugars. I was banded a week ago tomorrow and took myself off Byetta until I am through with my 3 week liquid diet as I thought it might be the cause of the stomach upset I was experiencing the first few days but I plan to begin using again as soon as I start eating real food. If it were me, and I could not get my sugars under control, I would definitely check with my diabetes care giver about using it again for that.