I had gastric bypass surgery on August 24. It’s just over a month later and I’m feeling like my Cymbalta is not working. I’ve noticed I have been feeling depressed which I initially just attributed to the surgery but now I’m wondering if my body is even absorbing the medicine like it should. I did not have any problems with the dosage prior to surgery.

If it's delayed- or extended-release, you won't absorb enough of it before it passes through. I don't know the formulary for Cymbalta but I had to change from Wellbutrin XL to Wellbutrin SR (which spiked my anxiety) to Wellbutrin IR. Talk to your psychiatrist.

Edited September 26, 20214 yr by vikingbeast

I don't deal with depression issues (fortunately...), but i know a lot of people who do have to have their meds changed or dosages adjusted after WLS - so check with your doctor.

I take cymbalta at night

As others have said, if it's an extended or delayed release, its possible you aren't absorbing it. Definitely contact your provider and discuss. There are tons of great meds put there that can work for WLS patients if you determine you need a med change. Even if it is just "post-op blues" it's so, so important to stay on top of your mental health throughout this process. I know it can feel overwhelming, but don't give up! You got this!

Remember your system is being flooded with hormones that were stored in fatty tissue. I had same issue immediately after surgery. Increased dosage for a period, than was able to taper back. As always, check with Dr who understands both depression and BariatricPal surgery.