It was one year in mid July that I had gastric sleeve surgery - one thing that has greatly changed is the way my body metabolizes medications. A sleeping pill use to last 8 hours - now 2 hours, my tylenol stops working in 3 hours, just changes with all my meds - anyone else have this occur? Any tips on how to make meds stay in system longer?

I don't, but perhaps a trip to your doctor is warranted. Those kinds of drugs are metabolized by the liver, so maybe getting a liver panel drawn (LFTs) might provide some insight. Good luck to you.