I had surgery in November 2010, and have been taking (1) generic lansoprazole daily since then. I had no complaints, felt great. Recently I found out that I have become allergic to it. I get this allergy through out my body. It is probably caused by the prolonged use of the PPI. I try not taking it but I cannot live with the acid reflux. After a couple of days of taking the acid reflux medicine I break out. I've tried taking tums, mylanta, etc. but they don't work well. I've also tried omeprazole, but again I get the allergy. I need to see my doctor obviously, but I was wondering if anyone had this issue...

I was allergic to something started at the hospital (which was everything but the Omeprazole pill), but I have no idea what. Since most of it was not optional, I was given Predinose and Sucralfate (coats the stomach, to help offset the problems Prednisone can cause) to take for a few weeks. Currently I'm only on the Omeprazole and not having any problems.

Neutralizers like Tums & Mylanta seem to be generally ineffective with us. Have you tried Pepcid? (Famotidine) It's not a PPI, but is an H2 blocker -- it reduces acid production andis a histamine blocker. When I went to the ER for treatment of the allergy noted above, a Pepcid bolus was the first thing they gave me. The Dr. advised always having it on hand, just in case.

Hi Wheetsin, thanks for the quick reply. How long have you been on the omeprazole? I have read about H2 blockers vs PPI's. I have not tried it, but that is my next intent. I hope it solves this problem. I hate the fact that I am allergic to lansoprozole, I wish I could stop taking it everything completely, but I can't live with acid reflux. I hope eventually it goes away forever!