I tried Contrave just as it first came out. The Wellbutrin portion of Contrave improved my mood, and the Naltrexone portion of Contrave helped relieve general aches & pains. Contrave also completely relieved any of my food cravings and appetite, however, I could not stay on it long because I am one of the rare individuals who ended up with a Parkinsonian-like response from the drug. I was odd, expressionless, and felt like I could not move or function; like moving through quicksand. I also got a very bad migraine after the fourth day on the lowest dose, so had to quit after the first week. I have tried all the new and old obesity medications, but the side effects are bad for me every time, not to mention the cost on some of the newer ones like Belviq. Thank you to the help of BariatricPal, I had the mini gastric bypass one week ago with Dr. Zavalza in Mexico. Best decision I've ever made, and cheaper in the long run than taking the medications for even just 1 1/2 years.