Question for anyone who takes Trintellix or other new gen SSRI. I was taking prior to surgery stopped and thought I was good. Realized today that I need to be on them. I have so much stress at work and feel like I am a b***h all the time. I was also taking Vyvanse and want to restart it too. Any thoughts?

17 hours ago, jaksmommy said:

Thanks to everyone that replied. The worst thing I have ever gone through was the sudden need for psychiatric meds 10 years ago. I would rather have a broken bone than go through the 2 or 3 weeks it took to find a combination of drugs that worked. I will talk to my psychologist about a possible replacement for cymbalta and ask about the siblingual Lamotrogine. I really appreciate the help.

Your first several sentences are exactly what I felt, although to be honest, I am still (After 10 years) trying to find a complete remission of anxiety. I don't think the average person understands how much these mental issues physiologically affect someone. Many a friend had an isolated bout of anxiety and as I walked them through it, they would often remark "Boy you're good at this" and then after it was over "Is this literally what you deal with, all the time" - Yep. Sucks doesn't it?

I wouldn't wish these things on anyone. And frankly I wish mental disorders didn't have such negative connotations against them.

On 7/9/2018 at 7:28 PM, priscillagreene said:

Question for anyone who takes Trintellix or other new gen SSRI. I was taking prior to surgery stopped and thought I was good. Realized today that I need to be on them. I have so much stress at work and feel like I am a b***h all the time. I was also taking Vyvanse and want to restart it too. Any thoughts?

I am on an SSRI, and was on liquid post-op until last week when I was told I could start taking my pills again. THANK GAWD! I would be absolutely terrified to just stop cold-turkey with my pills. Anything I've read online suggests weaning myself at a very slow rate, should I decide to try it, but NOT WITHOUT a doctor's consult and checks. If I were you, I'd start it back up. Of course, by now you probably already have an answer to your first post. I decided, for myself, that I would be staying on my SSRI for at least my surgery because of all the posts I've seen about depression. Thankfully (PRAISE TO GOD) I have not struggled at all. And since I am NO spring chicken and probably also experiencing pre-menopause, I might as well make it my candy for life

Just following up on this. Did you ever try the TRINTELLIX, OP? About 3 weeks post op the celexa just pooped out me and it had libido side effects that were no bueno! So- my provider just switched me to TRINTELLIX to give that a trial. She also switched my bupropion to the regular kind and not the sustained release kind. She said, “no wonder you started going down!”

Hopefully this combo works, because I was in a really great place with the cymbalta and Wellbutrin XL combo and I’d like to get back to that motivated, happy place. :)

On 8/24/2018 at 4:08 PM, insta_adventurer said:

Just following up on this. Did you ever try the TRINTELLIX, OP? About 3 weeks post op the celexa just pooped out me and it had libido side effects that were no bueno! So- my provider just switched me to TRINTELLIX to give that a trial. She also switched my bupropion to the regular kind and not the sustained release kind. She said, “no wonder you started going down!”

Hopefully this combo works, because I was in a really great place with the cymbalta and Wellbutrin XL combo and I’d like to get back to that motivated, happy place.

I'm not sure about the libido issues and SSRI's and how differently they affect women, but speaking from my own experience, they are all terrible, with the only exception being Luvox. It's one of the older, not commonly prescribed ones, as a matter of fact, you can only get it as a generic, but it has a minimal-to-moderate affect on me. Obviously Wellbutrin (Which hits the dopamine receptors really hard) improves libido many orders of magnitude. I wish it would work for me, but it makes my anxiety way, way worse. Going on a regular strength will probably help quite a bit. You could also see if you can get the smallest dose possible and take the meds several times a day for better absorption. Not sure if you realized it by your previous combo hit all three of the neurotransmitters, Serotonin, Norepinephrine and Dopamine. I just looked at the Trintellix wiki and it is a funky med in that it messes with the serotonin subtypes differently. Your current cocktail doesn't (appreciably) affect your norepinephrine receptors, so (In my non-formally-educated-in-pharmocology opinion), you might still lose the activation/energy that the norepinephrine provides.