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Interesting Article

Just thought I'd share a study I found in one of my medical journey subscriptions. Interesting read!

Sleeve Gastrectomy Improves Testosterone Levels in Obese Men

Thu, 10/08/15 - 11:39

Sleeve gastrectomy can normalize testosterone levels in men with obesity-related hypogonadism, according to a recent study.

Previous research has suggested both the potential benefits of bariatric surgery to overall health and potential adverse effects of testosterone replacement therapy. For this reason, researchers aimed to investigate the effects of surgery-related weight loss on serum testosterone and prostate-specific antigen (PSA) levels.

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In their study, they followed 24 men undergoing laparoscopic sleeve gastrectomy, measuring their serum testosterone, dehydroepiandrosterone (DHEA), and PSA levels before surgery, then again 3, 6, and 12 months after.

Overall, the amount of men in the study with low serum testosterone levels dropped from 63% to 41% 12 months after surgery.

“Our cohort experienced a significant increase in average serum testosterone as quickly as 3 months after sleeve gastrectomy and by 12 months, this value had increased from 295 to 423 ng/dL (p=0.003). DHEA showed a trend toward increase, from 12.8 to 39.6 ng/mL (p=0.12) and serum PSA concentration rose over 12 months from 0.62 to 0.75 ng/mL (p=0.047) with no change in PSA mass.”

“The take home message is that if you are an obese man with low testosterone your therapy should be weight loss not testosterone replacement, and a successful way to achieve meaningful weight loss is through a bariatric operation,” they concluded.

“This is a unique and beneficial finding for sleeve gastrectomy hasn’t been studied before, demonstrating for the first time, that testosterone levels are improved in a group of obese male patients following sleeve gastrectomy.”

—Michael Potts

References:

Morton JM, Mokhrati T, Nair AA, et al. Male sex hormones normalize after laparoscopic sleeve gastrectomy. Paper presented at: The 2015 Clinical Congress of the American College of Surgeons. Chicago, IL. October 5, 2015.

American College of Surgeons. Testosterone Levels Improve in Obese Men Following a Common Weight-Loss Operation [press release]. October 5, 2015. https://www.facs.org/media/press-releases/2015/morton.

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